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Its specialized action on VAT makes Tesamorelin ideal for individuals whose main goal is to improve body composition, reduce disease risk, and target abdominal obesity

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Typically, one injection is given daily or every other day for one to two weeks, followed by injections twice a week for a few weeks

Severely obese patients may be good candidates as well

In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism in rodents and in human adipose tissue